{"id":3780,"date":"2015-04-23T19:01:00","date_gmt":"2015-04-23T19:01:00","guid":{"rendered":"http:\/\/news.truthjuice.co.uk\/index.php\/the-transhuman-age-is-here-but-not-quite-yet-crisprcas9-used-to-modify-human-embryos\/"},"modified":"2015-05-31T17:07:33","modified_gmt":"2015-05-31T17:07:33","slug":"the-transhuman-age-is-here-but-not-quite-yet-crisprcas9-used-to-modify-human-embryos","status":"publish","type":"post","link":"https:\/\/news.truthjuice.co.uk\/index.php\/the-transhuman-age-is-here-but-not-quite-yet-crisprcas9-used-to-modify-human-embryos\/","title":{"rendered":"The Transhuman Age is Here (But Not Quite Yet) \u2014 CRISPR\/Cas9 Used to Modify Human Embryos"},"content":{"rendered":"

The published report confirms previous rumors and speculation<\/a> that such experiments had been conducted, and confirmed the position that these experiments would indeed be conducted regardless of any moratorium on the work<\/a>. Previously, the\u00a0CRISPR<\/a>\/Cas9 system had only\u00a0been demonstrated in\u00a0adult human cells and with animal embryos.<\/p>\n

\"Screen<\/p>\n

In their paper, the team\u00a0led by Junjiu Huang who is a gene function researcher at Sun Yat-sen University<\/a> used only non-viable embryos which cannot be implanted and\u00a0result in a live birth. Their publication\u00a0reports that the method was successfully able to\u00a0modify the gene responsible for \u03b2-thalassaemia, a potentially fatal blood disorder. However, the researchers also report\u00a0that their results show that there remain serious obstacles to using the method in medical applications anytime in the near future.<\/p>\n

In this procedure, embryos are injected with the enzyme complex CRISPR\/Cas9, which binds and splices DNA<\/a> at specific locations along the double helix. The CRISPR\/Cas9 enzyme complex can be programmed to locate\u00a0a specific problematic gene of interest which is then replaced.<\/p>\n

In this experiment the Chinese scientists tested to see if the technique could\u00a0replace a gene in a single-cell fertilized human embryo. Then, in theory, all cells produced as the embryo developed would then have the repaired gene.<\/p>\n

However, the Chinese team reports that of the injected 86 embryos only\u00a071 survived, and of these 59 were genetically tested. Only\u00a028 of those embryos were successfully spliced by CRISPR\/Cas9 and of these only a fraction of the embryos contained the correctly modified DNA sequence, specifically only 14 samples\u00a0perfectly matched the donor.<\/p>\n

The researchers conclude that “off-target effect of CRISPR\/ Cas9 should be investigated thoroughly before any clinical application” of the technique\u00a0and\u00a0that “CRISPR\/Cas9 has off-target effect in human tripronuclear embryos” therefore “our work highlights the pressing need to further improve the fidelity and specificity of the CRISPR\/Cas9 platform” and that such improvements would be “a prerequisite for any clinical applications of CRSIPR\/Cas9-mediated editing.”<\/p>\n

This publication was widely reported in the mainstream media to be the\u00a0first germline modification of humans, however\u00a0as reported\u00a0only non-viable embryos were used. So arguably\u00a0this is not a true real world germline modification. It is of course an important experiment that shows such modification is indeed technically possible. However, this was largely suspected already based on existing demonstrated work with animal embryos.<\/p>\n

The results are at this time negative for clinical use since\u00a0the experiment\u00a0suggests that the CRISPR\/Cas9 method is not specific enough in its action and also it was in the end relatively ineffective at performing the desired modification producing only 14\/71 correctly modified embryos.<\/p>\n

 <\/p>\n

The post The Transhuman Age is Here (But Not Quite Yet) — CRISPR\/Cas9 Used to Modify Human Embryos<\/a> appeared first on h+ Media<\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"

The published report confirms previous rumors and speculation that such experiments had been conducted, and confirmed the position that these experiments would indeed be conducted regardless of any moratorium on the work. Previously, the\u00a0CRISPR\/Cas9 system had only\u00a0been demonstrated in\u00a0adult human cells and with animal embryos. In their paper, the team\u00a0led by Junjiu Huang who is … <\/p>\n

Continue reading »<\/a><\/p>\n","protected":false},"author":7,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[78,69],"tags":[],"class_list":["post-3780","post","type-post","status-publish","format-standard","hentry","category-tj-archive","category-transhumanism","nodate"],"yoast_head":"\nThe Transhuman Age is Here (But Not Quite Yet) \u2014 CRISPR\/Cas9 Used to Modify Human Embryos - TruthJuice News<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/news.truthjuice.co.uk\/index.php\/the-transhuman-age-is-here-but-not-quite-yet-crisprcas9-used-to-modify-human-embryos\/\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"The Transhuman Age is Here (But Not Quite Yet) \u2014 CRISPR\/Cas9 Used to Modify Human Embryos - TruthJuice News\" \/>\n<meta property=\"og:description\" content=\"The published report confirms previous rumors and speculation that such experiments had been conducted, and confirmed the position that these experiments would indeed be conducted regardless of any moratorium on the work. Previously, the\u00a0CRISPR\/Cas9 system had only\u00a0been demonstrated in\u00a0adult human cells and with animal embryos. In their paper, the team\u00a0led by Junjiu Huang who is … Continue reading »\" \/>\n<meta property=\"og:url\" content=\"https:\/\/news.truthjuice.co.uk\/index.php\/the-transhuman-age-is-here-but-not-quite-yet-crisprcas9-used-to-modify-human-embryos\/\" \/>\n<meta property=\"og:site_name\" content=\"TruthJuice News\" \/>\n<meta property=\"article:published_time\" content=\"2015-04-23T19:01:00+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2015-05-31T17:07:33+00:00\" \/>\n<meta property=\"og:image\" content=\"http:\/\/news.truthjuice.co.uk\/wp-content\/plugins\/wp-o-matic\/cache\/b72afe699b_Screen-Shot-2015-04-23-at-11-29-30-AM.png\" \/>\n<meta name=\"author\" content=\"The Architect\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"The Architect\" \/>\n\t<meta name=\"twitter:label2\" content=\"Estimated reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/news.truthjuice.co.uk\/index.php\/the-transhuman-age-is-here-but-not-quite-yet-crisprcas9-used-to-modify-human-embryos\/\",\"url\":\"https:\/\/news.truthjuice.co.uk\/index.php\/the-transhuman-age-is-here-but-not-quite-yet-crisprcas9-used-to-modify-human-embryos\/\",\"name\":\"The Transhuman Age is Here (But Not Quite Yet) \u2014 CRISPR\/Cas9 Used to Modify Human Embryos - TruthJuice News\",\"isPartOf\":{\"@id\":\"https:\/\/news.truthjuice.co.uk\/#website\"},\"datePublished\":\"2015-04-23T19:01:00+00:00\",\"dateModified\":\"2015-05-31T17:07:33+00:00\",\"author\":{\"@id\":\"https:\/\/news.truthjuice.co.uk\/#\/schema\/person\/850fb4325758ef62e0feb0b6af06e039\"},\"breadcrumb\":{\"@id\":\"https:\/\/news.truthjuice.co.uk\/index.php\/the-transhuman-age-is-here-but-not-quite-yet-crisprcas9-used-to-modify-human-embryos\/#breadcrumb\"},\"inLanguage\":\"en-GB\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/news.truthjuice.co.uk\/index.php\/the-transhuman-age-is-here-but-not-quite-yet-crisprcas9-used-to-modify-human-embryos\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/news.truthjuice.co.uk\/index.php\/the-transhuman-age-is-here-but-not-quite-yet-crisprcas9-used-to-modify-human-embryos\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/news.truthjuice.co.uk\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"The Transhuman Age is Here (But Not Quite Yet) \u2014 CRISPR\/Cas9 Used to Modify Human Embryos\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/news.truthjuice.co.uk\/#website\",\"url\":\"https:\/\/news.truthjuice.co.uk\/\",\"name\":\"TruthJuice News\",\"description\":\"For the Truthseeker and Freethinker\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/news.truthjuice.co.uk\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"en-GB\"},{\"@type\":\"Person\",\"@id\":\"https:\/\/news.truthjuice.co.uk\/#\/schema\/person\/850fb4325758ef62e0feb0b6af06e039\",\"name\":\"The Architect\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-GB\",\"@id\":\"https:\/\/news.truthjuice.co.uk\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/50e2c7869b4d2fcd7a3645c24b01bed4a88e8ed18aa2947c61c25e43732bea35?s=96&d=wavatar&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/50e2c7869b4d2fcd7a3645c24b01bed4a88e8ed18aa2947c61c25e43732bea35?s=96&d=wavatar&r=g\",\"caption\":\"The Architect\"},\"sameAs\":[\"http:\/\/www.truthjuice.co.uk\"],\"url\":\"https:\/\/news.truthjuice.co.uk\/index.php\/author\/the-architect\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"The Transhuman Age is Here (But Not Quite Yet) \u2014 CRISPR\/Cas9 Used to Modify Human Embryos - TruthJuice News","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/news.truthjuice.co.uk\/index.php\/the-transhuman-age-is-here-but-not-quite-yet-crisprcas9-used-to-modify-human-embryos\/","og_locale":"en_GB","og_type":"article","og_title":"The Transhuman Age is Here (But Not Quite Yet) \u2014 CRISPR\/Cas9 Used to Modify Human Embryos - TruthJuice News","og_description":"The published report confirms previous rumors and speculation that such experiments had been conducted, and confirmed the position that these experiments would indeed be conducted regardless of any moratorium on the work. Previously, the\u00a0CRISPR\/Cas9 system had only\u00a0been demonstrated in\u00a0adult human cells and with animal embryos. In their paper, the team\u00a0led by Junjiu Huang who is … Continue reading »","og_url":"https:\/\/news.truthjuice.co.uk\/index.php\/the-transhuman-age-is-here-but-not-quite-yet-crisprcas9-used-to-modify-human-embryos\/","og_site_name":"TruthJuice News","article_published_time":"2015-04-23T19:01:00+00:00","article_modified_time":"2015-05-31T17:07:33+00:00","og_image":[{"url":"http:\/\/news.truthjuice.co.uk\/wp-content\/plugins\/wp-o-matic\/cache\/b72afe699b_Screen-Shot-2015-04-23-at-11-29-30-AM.png"}],"author":"The Architect","twitter_misc":{"Written by":"The Architect","Estimated reading time":"2 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/news.truthjuice.co.uk\/index.php\/the-transhuman-age-is-here-but-not-quite-yet-crisprcas9-used-to-modify-human-embryos\/","url":"https:\/\/news.truthjuice.co.uk\/index.php\/the-transhuman-age-is-here-but-not-quite-yet-crisprcas9-used-to-modify-human-embryos\/","name":"The Transhuman Age is Here (But Not Quite Yet) \u2014 CRISPR\/Cas9 Used to Modify Human Embryos - TruthJuice News","isPartOf":{"@id":"https:\/\/news.truthjuice.co.uk\/#website"},"datePublished":"2015-04-23T19:01:00+00:00","dateModified":"2015-05-31T17:07:33+00:00","author":{"@id":"https:\/\/news.truthjuice.co.uk\/#\/schema\/person\/850fb4325758ef62e0feb0b6af06e039"},"breadcrumb":{"@id":"https:\/\/news.truthjuice.co.uk\/index.php\/the-transhuman-age-is-here-but-not-quite-yet-crisprcas9-used-to-modify-human-embryos\/#breadcrumb"},"inLanguage":"en-GB","potentialAction":[{"@type":"ReadAction","target":["https:\/\/news.truthjuice.co.uk\/index.php\/the-transhuman-age-is-here-but-not-quite-yet-crisprcas9-used-to-modify-human-embryos\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/news.truthjuice.co.uk\/index.php\/the-transhuman-age-is-here-but-not-quite-yet-crisprcas9-used-to-modify-human-embryos\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/news.truthjuice.co.uk\/"},{"@type":"ListItem","position":2,"name":"The Transhuman Age is Here (But Not Quite Yet) \u2014 CRISPR\/Cas9 Used to Modify Human Embryos"}]},{"@type":"WebSite","@id":"https:\/\/news.truthjuice.co.uk\/#website","url":"https:\/\/news.truthjuice.co.uk\/","name":"TruthJuice News","description":"For the Truthseeker and Freethinker","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/news.truthjuice.co.uk\/?s={search_term_string}"},"query-input":"required name=search_term_string"}],"inLanguage":"en-GB"},{"@type":"Person","@id":"https:\/\/news.truthjuice.co.uk\/#\/schema\/person\/850fb4325758ef62e0feb0b6af06e039","name":"The Architect","image":{"@type":"ImageObject","inLanguage":"en-GB","@id":"https:\/\/news.truthjuice.co.uk\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/50e2c7869b4d2fcd7a3645c24b01bed4a88e8ed18aa2947c61c25e43732bea35?s=96&d=wavatar&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/50e2c7869b4d2fcd7a3645c24b01bed4a88e8ed18aa2947c61c25e43732bea35?s=96&d=wavatar&r=g","caption":"The Architect"},"sameAs":["http:\/\/www.truthjuice.co.uk"],"url":"https:\/\/news.truthjuice.co.uk\/index.php\/author\/the-architect\/"}]}},"_links":{"self":[{"href":"https:\/\/news.truthjuice.co.uk\/index.php\/wp-json\/wp\/v2\/posts\/3780","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/news.truthjuice.co.uk\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/news.truthjuice.co.uk\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/news.truthjuice.co.uk\/index.php\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/news.truthjuice.co.uk\/index.php\/wp-json\/wp\/v2\/comments?post=3780"}],"version-history":[{"count":1,"href":"https:\/\/news.truthjuice.co.uk\/index.php\/wp-json\/wp\/v2\/posts\/3780\/revisions"}],"predecessor-version":[{"id":4611,"href":"https:\/\/news.truthjuice.co.uk\/index.php\/wp-json\/wp\/v2\/posts\/3780\/revisions\/4611"}],"wp:attachment":[{"href":"https:\/\/news.truthjuice.co.uk\/index.php\/wp-json\/wp\/v2\/media?parent=3780"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/news.truthjuice.co.uk\/index.php\/wp-json\/wp\/v2\/categories?post=3780"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/news.truthjuice.co.uk\/index.php\/wp-json\/wp\/v2\/tags?post=3780"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}